ACRP ACRP-CP Q&A - in .pdf

  • Exam Code: ACRP-CP
  • Exam Name: ACRP Certified Professional Exam
  • Updated: Oct 02, 2026
  • Q & A: 127 Questions and Answers
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ACRP ACRP-CP Q&A - Testing Engine

  • Exam Code: ACRP-CP
  • Exam Name: ACRP Certified Professional Exam
  • Updated: Oct 02, 2026
  • Q & A: 127 Questions and Answers
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ACRP ACRP-CP Exam Syllabus Topics:

SectionWeightObjectives
Clinical Study Operations15%- Project management
  • 1. Timeline and budget management
  • 2. Vendor and stakeholder management
- Site management
  • 1. Site personnel training and delegation
  • 2. Study documentation and record keeping
Professionalism and Ethical Practice15%- Continuous improvement
  • 1. Professional development and education
  • 2. Quality assurance and process improvement
- Professional standards
  • 1. Confidentiality and conflict of interest
  • 2. Role responsibilities and boundaries
Data Management and Informatics17%- Data collection
  • 1. Case report form design and completion
  • 2. Electronic data capture systems
- Data quality control
  • 1. Query management and resolution
  • 2. Data validation and cleaning
- Data reporting
  • 1. Data integrity and security
  • 2. Database lock and data transfer
Ethical and Participant Safety Considerations19%- Safety monitoring and reporting
  • 1. Adverse event identification and classification
  • 2. Safety information evaluation and communication
- Ethical principles
  • 1. Clinical equipoise and therapeutic misconception
  • 2. Human subject protections and privacy
- Clinical care and management of research participants
  • 1. Standard of care vs protocol requirements
  • 2. Continuity of medical care
  • 3. Informed consent development and review
Regulatory and Compliance Requirements17%- Compliance procedures
  • 1. Audits and inspections
  • 2. Regulatory submissions and approvals
- International standards
  • 1. Declaration of Helsinki
- ICH Guidelines
  • 1. E9 Statistical Principles
  • 2. E2A Expedited Reporting
  • 3. E6(R2)/E6(R3) Good Clinical Practice
  • 4. E11 Pediatric Trials
  • 5. E8 General Considerations for Clinical Trials
Study Design and Conduct17%- Study planning
  • 1. Sample size and statistical considerations
  • 2. Study population and eligibility criteria
  • 3. Protocol development and amendments
- Study implementation
  • 1. Site selection and activation
  • 2. Investigational product management
  • 3. Study monitoring and oversight

ACRP Certified Professional Sample Questions:

Question #1

A protocol inclusion criterion requires the serum magnesium at screening to be within the normal range. After the subject received IP, the CRC discovers the subject's screening magnesium level was below the normal range and the sub-investigator marked the lab sheet as not clinically significant. Which of the following should be done FIRST?

  • A. Notify the sponsor.
  • B. Notify the subject.
  • C. Notify the regulatory authority.
  • D. Withdraw the subject.
Reveal Solution  Discussion  0

Correct Answer: A  🗳️

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Question #2

An investigator participating in a multicenter clinical trial has had 2 of the 4 subjects admitted to the emergency room for life-threatening infections. The investigator made the decision to stop treatment with IP and test for infections in the remaining subjects. What are the NEXT steps the investigator should take?

  • A. Add the risk of infection to the ICF and submit to the IRB/IEC for review.
  • B. Discontinue current subjects from the study and monitor subjects for any anticipated safety events.
  • C. Notify the sponsor of the change in study plan and submit the deviation to the IRB/IEC for review.
  • D. Update the IB to add the risk of infection and submit to the sponsor for approval.
Reveal Solution  Discussion  0

Correct Answer: C  🗳️

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Question #3

An interim analysis is conducted during a clinical trial. To review the results, the sponsor assigns:

  • A. Independent qualified individuals.
  • B. Executive board members.
  • C. Investigators participating in the trial.
  • D. Regulatory authority expert advisors.
Reveal Solution  Discussion  0

Correct Answer: A  🗳️

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Question #4

The PI may assign responsibility for IP accountability to the pharmacist provided they are:

  • A. An employee of the institution.
  • B. Approved by the IRB/IEC.
  • C. Under the supervision of the PI.
  • D. Licensed to practice medicine.
Reveal Solution  Discussion  0

Correct Answer: C  🗳️

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Question #5

Who is responsible to ensure training for key staff members unable to attend the site initiation visit?

  • A. Coordinator
  • B. Monitor
  • C. Investigator
  • D. Sponsor
Reveal Solution  Discussion  0

Correct Answer: C  🗳️

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